Borate buffered saline has been used to determine whether heat-killed, borate-buffered suspensions of Gordonia bronchialis, Rhodococcus coprophilus or Tsukamurella inchonensis can be used to treat canine flea allergy. Borate buffered saline has also been used to investigate the effects of lentivirus mediated siRNA targeting human metastasis suppressor 1 (MTSS1, MIM-B gene) gene on the invasive and metastatic potentials of hepatocellular carcinoma (HCC) MHCC97H cells. Borate buffered saline has been used to determine the effects of packaging solution osmolality and buffering agent on soft contact lens parameters.

1 tablet in 500 mL water yields in 0.010 M borate buffer, 0.15 M NaCl, pH 8.2