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Cycloheximide, also known as Actidione, is a glutarimide antibiotic commonly derived from the bacterium Streptomyces griseus. It acts as a potent inhibitor of protein biosynthesis in eukaryotic cells by disrupting the translocation step during translation, effectively blocking translational elongation. In microbiology, it plays a crucial role as a selection agent for resistant strains of yeast and fungi, proving invaluable in controlled experimental environments.
biological source
microbial
Quality Level
Assay
≥94% (TLC)
form
powder
color
white to off-white
solubility
ethanol: soluble, clear to hazy
antibiotic activity spectrum
fungi
yeast
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
English
